Revolution Medicines is hiring for work from home roles

Revolution Medicines

57 Remote Job Openings at Revolution Medicines

Senior Director, Clinical Operations, Japan

Revolution Medicines · Full Time · a day ago
Revolution Medicines
🌎 Japan ⭐ 10+ yrs exp 💼 Healthcare
Responsible for the operational design, structure, and execution of early-stage clinical studies in Japan. This includes managing the Clinical Development Plan, overseeing CRO and site selection, and leading clinical operations resources.

Senior Director, Economic Modeling

Revolution Medicines · Full Time · a day ago
Revolution Medicines
🌎 Switzerland ⭐ 10+ yrs exp 💼 Others
Lead the definition and execution of the economic modeling strategy to produce high-quality health economic models across the company's oncology portfolio. This includes overseeing HTA submissions, payer evidence generation, and the integration of evolving HTA guidelines.

Senior Director, Access Strategy & Marketing

Revolution Medicines · Full Time · 5 days ago
Revolution Medicines
🌎 United States 💵 $232K - $290K per year ⭐ 10+ yrs exp 💼 Marketing
Lead the development and execution of access strategy, non-clinical positioning, and marketing materials for the oncology portfolio, specifically focusing on NSCLC. Build and manage a team of Access Marketers while coordinating launch readiness across the Market Access function.

Senior Director, Access Strategy & Marketing

Revolution Medicines · Full Time · 5 days ago
Revolution Medicines
🌎 United States 💵 $232K - $290K per year ⭐ 10+ yrs exp 💼 Marketing
Lead the development and execution of access strategy, non-clinical positioning, and marketing materials for the oncology portfolio. Build and manage a team of Access Marketers while coordinating launch readiness across the Market Access function.

Senior Manager, Medical Excellence and Operations, Japan

Revolution Medicines · Full Time · 6 days ago
Revolution Medicines
🌎 Japan ⭐ 5-10 yrs exp 💼 Healthcare
Establish and oversee medical governance frameworks, including Medical Review Committees and SOPs, to ensure operational excellence. Manage contracting, vendor oversight, and the execution of medical projects in alignment with global and regional stakeholders.

Senior Director, Global Finance

Revolution Medicines · Full Time · 6 days ago
Revolution Medicines
🌎 United States 💵 $232K - $290K per year ⭐ 10+ yrs exp 💼 Finance
Lead the finance workstream for launching and operationalizing finance operations in new international markets. Establish global controllership standards, govern accounting processes, and manage the transition to steady-state local or outsourced operating models.

Associate Director, HEOR/RWE GI

Revolution Medicines · Full Time · 7 days ago
Revolution Medicines
🌎 United States 💵 $186K - $233K per year ⭐ 5-10 yrs exp 💼 Others
Execute HEOR and RWE strategies to generate evidence demonstrating the value of gastrointestinal cancer therapies to healthcare organizations. Collaborate with Medical Affairs and cross-functional teams to optimize the Integrated Evidence Plan and communicate value insights to internal and external stakeholders.

Director, Commercial, Switzerland

Revolution Medicines · Full Time · 8 days ago
Revolution Medicines
🌎 Switzerland ⭐ 10+ yrs exp 💼 Others
The Commercial Lead is responsible for defining and executing the local commercial strategy and building the commercial organization for the oncology portfolio in Switzerland. This includes driving launch performance, managing the field force, and aligning with Medical Affairs and Market Access functions.

Director, Medical Science Liaison, GI – Oncology (Northern Florida, GA, SC, AL)

Revolution Medicines · Full Time · 8 days ago
Revolution Medicines
🌎 United States 💵 $236K - $259K per year ⭐ 10+ yrs exp 💼 Healthcare
The MSL will cultivate professional relationships with Key Opinion Leaders and healthcare providers to advance scientific knowledge of RAS-addicted cancers. They will serve as a therapeutic expert, providing scientific support for medical congresses, advisory boards, and internal cross-functional teams.

Associate Director, HEOR, Japan

Revolution Medicines · Full Time · 14 days ago
Revolution Medicines
🌎 Japan ⭐ 5-10 yrs exp 💼 Others
Lead the HEOR strategy in Japan to optimize value demonstration for the oncology portfolio through evidence generation and integrated planning. Collaborate with global and regional teams to align HEOR insights with market access, pricing, and reimbursement strategies.

Associate Director, Medical Lead GI, Japan

Revolution Medicines · Full Time · 14 days ago
Revolution Medicines
🌎 Japan ⭐ 5-10 yrs exp 💼 Healthcare
Develop and execute the Japan Medical Affairs strategy for Gastrointestinal and Pancreatic cancers, focusing on evidence generation and publication. Build and maintain scientific relationships with key opinion leaders and provide medical oversight to cross-functional teams.

Senior Manager, Medical Science Liaison, Japan

Revolution Medicines · Full Time · 14 days ago
Revolution Medicines
🌎 Japan ⭐ 5-10 yrs exp 💼 Healthcare
The MSL will cultivate professional relationships with Key Opinion Leaders and healthcare providers in Japan to support the company's oncology pipeline. They will provide scientific expertise to internal teams and support medical education, advisory boards, and clinical study sites.

Director, Global Pre-Approval Patient Access

Revolution Medicines · Full Time · a month ago
Revolution Medicines
🌎 United States 💵 $201K - $251K per year ⭐ 10+ yrs exp 💼 Others
Lead the strategy, design, and execution of global early access programs for investigational oncology therapies. Coordinate across clinical, regulatory, and commercial teams to ensure ethical patient access and supply readiness.

Director, Supply Chain & Wholesaler Relations - Japan

Revolution Medicines · Full Time · a month ago
Revolution Medicines
🌎 Japan ⭐ 10+ yrs exp 💼 Others
Lead the establishment of Japan's commercial supply chain infrastructure from the ground up to ensure operational readiness for product launch. This includes managing wholesaler selection, 3PL setup, and coordinating distribution strategies with global and local stakeholders.

Associate Director, Accounting - Japan

Revolution Medicines · Full Time · a month ago
Revolution Medicines
🌎 Japan ⭐ 10+ yrs exp 💼 Finance
Lead accounting operations, financial reporting, and statutory compliance for the Japan entity to support commercial readiness. Establish scalable finance infrastructure, including the implementation of core financial systems and the design of Order-to-Cash processes.

Regional Insights and Engagement Director, Lung, Southeast

Revolution Medicines · Full Time · a month ago
Revolution Medicines
🌎 United States 💵 $231K - $254K per year ⭐ 10+ yrs exp 💼 Others
Lead engagement with Lung Cancer Key Opinion Leaders in the Southeast region to inform brand strategy and execute commercial tactics. Collaborate cross-functionally to support the US launch of RAS(ON) inhibitors and communicate market insights to the organization.

Regional Insights and Engagement Director, Northeast

Revolution Medicines · Full Time · a month ago
Revolution Medicines
🌎 United States 💵 $231K - $254K per year ⭐ 10+ yrs exp 💼 Others
Lead engagement with Lung Cancer Key Opinion Leaders in the Northeast to inform brand strategy and support the US launch of RAS(ON) inhibitors. Collaborate cross-functionally to develop marketing deliverables, execute congress plans, and communicate market insights to the organization.

Regional Insights and Engagement Director, Lung, Central Rockies

Revolution Medicines · Full Time · a month ago
Revolution Medicines
🌎 United States 💵 $231K - $254K per year ⭐ 10+ yrs exp 💼 Others
Lead engagement with Lung Cancer Key Opinion Leaders in the Central Rockies to inform brand strategy and execute commercial tactics. Collaborate cross-functionally to support the US launch of RAS(ON) inhibitors and communicate market insights to the organization.

Director, Medical Science Liaison, Oncology (Dallas, AR, LA, OK, MS)

Revolution Medicines · Full Time · a month ago
Revolution Medicines
🌎 United States 💵 $236K - $259K per year ⭐ 10+ yrs exp 💼 Software Development
The Director, MSL will engage in peer-to-peer scientific dialogue with healthcare professionals and KOLs to translate insights into medical strategy. They will serve as a therapeutic expert for internal teams and provide scientific support for clinical study sites, advisory boards, and medical congresses.

Director, Medical Science Liaison, Oncology (AZ, CO, NM, NV)

Revolution Medicines · Full Time · a month ago
Revolution Medicines
🌎 United States 💵 $236K - $259K per year ⭐ 10+ yrs exp 💼 Healthcare
The Director, MSL will engage in peer-to-peer scientific dialogue with healthcare professionals and KOLs to translate insights into medical strategies. They will serve as a therapeutic expert and liaison between the company and clinical study sites across Arizona, Colorado, New Mexico, and Nevada.

Director, Medical Science Liaison, Oncology (WA, OR, AK, MT, WY, ID, UT)

Revolution Medicines · Full Time · a month ago
Revolution Medicines
🌎 United States 💵 $236K - $259K per year ⭐ 10+ yrs exp 💼 Healthcare
The Director, MSL will cultivate relationships with key opinion leaders and healthcare providers to advance scientific knowledge of RAS-addicted cancers. They will serve as a therapeutic expert, providing scientific support for medical congresses, advisory boards, and internal cross-functional teams.

Director, Medical Science Liaison, Oncology Texas (Houston, Austin, San Antonio)

Revolution Medicines · Full Time · a month ago
Revolution Medicines
🌎 United States 💵 $236K - $259K per year ⭐ 10+ yrs exp 💼 Healthcare
The role involves engaging in peer-to-peer scientific dialogue with healthcare professionals and KOLs to gather insights and advance medical knowledge. The MSL will serve as a therapeutic expert and liaison between the company and clinical study sites, supporting medical congresses and advisory boards.

Director, Medical Science Liaison, Oncology (ND, SD, NE, MO, IA, KS)

Revolution Medicines · Full Time · a month ago
Revolution Medicines
🌎 United States 💵 $236K - $259K per year ⭐ 10+ yrs exp 💼 Healthcare
The Director, MSL will engage in peer-to-peer scientific dialogue with healthcare professionals to gather insights and cultivate relationships with Key Opinion Leaders. They will serve as a therapeutic expert for internal teams and provide scientific support for medical congresses and advisory boards.

Director, Medical Information, Japan

Revolution Medicines · Full Time · a month ago
Revolution Medicines
🌎 Japan ⭐ 10+ yrs exp 💼 Healthcare
Oversee the delivery of evidence-based medical information and manage the Japan medical information call center team. Develop scientific resources such as standard response letters and support medical activities at scientific congresses.

Director, Safety Management, Japan

Revolution Medicines · Full Time · a month ago
Revolution Medicines
🌎 Japan ⭐ 10+ yrs exp 💼 Others
Lead safety management activities for the Japan entity and serve as the designated Safety Management Manager (Anseki). Establish and oversee pharmacovigilance systems, ensure compliance with PMDA regulations, and collaborate within the three-role governance framework.

Director, Quality Assurance, Japan

Revolution Medicines · Full Time · a month ago
Revolution Medicines
🌎 Japan ⭐ 10+ yrs exp 💼 Software Development
Lead quality management and oversight for the Japan entity, serving as the designated Quality Assurance Manager (Hinseki) under GQP ordinances. Ensure compliance with Japanese GMP/GQP/GDP requirements and manage relationships with the PMDA and other regulatory authorities.

Director, Medical Science Liaison (Northern Florida, GA, SC, AL, MS)

Revolution Medicines · Full Time · a month ago
Revolution Medicines
🌎 United States 💵 $236K - $259K per year ⭐ 10+ yrs exp 💼 Healthcare
The Director, MSL will engage in peer-to-peer scientific dialogue with healthcare professionals and KOLs to translate insights into medical strategy. They will serve as a therapeutic expert for internal teams and provide scientific support for clinical study sites, advisory boards, and medical congresses.

Director, Medical Science Liaison (Northern California, Hawaii)

Revolution Medicines · Full Time · a month ago
Revolution Medicines
🌎 United States 💵 $236K - $259K per year ⭐ 10+ yrs exp 💼 Healthcare
The Director, MSL will engage in peer-to-peer scientific dialogue with healthcare professionals and cultivate relationships with Key Opinion Leaders in Northern California and Hawaii. They will serve as a therapeutic expert to internal teams and provide scientific support for medical congresses and advisory boards.

Director, Medical Science Liaison (NC, TN, KY, VA)

Revolution Medicines · Full Time · a month ago
Revolution Medicines
🌎 United States 💵 $236K - $259K per year ⭐ 10+ yrs exp 💼 Healthcare
The Director, MSL will engage in peer-to-peer scientific dialogue with healthcare professionals to gather insights and cultivate relationships with Key Opinion Leaders. They will serve as a therapeutic expert and liaison between the company and clinical study sites to support medical education and congresses.

Director, Medical Science Liaison (Boston, RI, RH, VT, ME)

Revolution Medicines · Full Time · a month ago
Revolution Medicines
🌎 United States 💵 $236K - $259K per year ⭐ 10+ yrs exp 💼 Healthcare
The Director, MSL will engage in peer-to-peer scientific dialogue with healthcare professionals and KOLs to translate insights into medical strategy. They will serve as a therapeutic expert for internal teams and provide scientific support for medical congresses and advisory boards.

Director, Medical Science Liaison (NYC, CT)

Revolution Medicines · Full Time · a month ago
Revolution Medicines
🌎 United States 💵 $236K - $259K per year ⭐ 10+ yrs exp 💼 Healthcare
The Director, MSL will engage in peer-to-peer scientific dialogue with healthcare professionals to gather insights and strengthen relationships with Key Opinion Leaders. They will serve as a therapeutic expert and liaison between the company and clinical study sites to support medical education and congresses.

Director, Medical Science Liaison (Southern Florida, Puerto Rico)

Revolution Medicines · Full Time · a month ago
Revolution Medicines
🌎 United States 💵 $236K - $259K per year ⭐ 10+ yrs exp 💼 Healthcare
The role involves engaging in peer-to-peer scientific dialogue with healthcare professionals and cultivating relationships with Key Opinion Leaders to advance medical knowledge. The MSL will act as a liaison between the company and clinical study sites while providing scientific support for congresses and advisory boards.

Director, Medical Science Liaison (Philadelphia, Hershey, NJ, MD, DC)

Revolution Medicines · Full Time · a month ago
Revolution Medicines
🌎 United States 💵 $236K - $259K per year ⭐ 10+ yrs exp 💼 Healthcare
The role involves engaging in peer-to-peer scientific dialogue with healthcare professionals and cultivating relationships with Key Opinion Leaders to advance medical knowledge. The MSL will act as a liaison between the company and clinical study sites while providing scientific support for congresses and advisory boards.

Director, Medical Science Liaison (OH, W. Virginia, W. PA, Upstate NY)

Revolution Medicines · Full Time · a month ago
Revolution Medicines
🌎 United States 💵 $236K - $259K per year ⭐ 10+ yrs exp 💼 Healthcare
The Director, MSL will cultivate relationships with Key Opinion Leaders and healthcare providers to advance scientific knowledge of RAS-addicted cancers. They will serve as a therapeutic expert, providing scientific support for medical congresses, advisory boards, and internal cross-functional teams.

Director, Medical Science Liaison (Southern California)

Revolution Medicines · Full Time · a month ago
Revolution Medicines
🌎 United States 💵 $236K - $259K per year ⭐ 10+ yrs exp 💼 Healthcare
The Director, MSL will engage in peer-to-peer scientific dialogue with healthcare professionals and KOLs to translate insights into medical strategy. They will serve as a therapeutic expert for internal teams and provide scientific support for medical congresses and advisory boards.

Director, Medical Science Liaison (IL, IN)

Revolution Medicines · Full Time · a month ago
Revolution Medicines
🌎 United States 💵 $236K - $259K per year ⭐ 10+ yrs exp 💼 Healthcare
The Director, MSL will engage in peer-to-peer scientific dialogue with healthcare professionals and KOLs to translate insights into medical strategy. They will serve as a therapeutic expert and liaison between the company and clinical study sites, supporting medical congresses and advisory boards.

Director, Medical Science Liaison (MI, WI, MN)

Revolution Medicines · Full Time · a month ago
Revolution Medicines
🌎 United States 💵 $236K - $259K per year ⭐ 10+ yrs exp 💼 Healthcare
The Director, MSL will engage in peer-to-peer scientific dialogue with healthcare professionals to gather insights and cultivate relationships with Key Opinion Leaders. They will serve as a therapeutic expert and liaison between the company and clinical study sites to support medical education and congresses.

Senior Director, Medical Affairs, Midsized Markets Europe

Revolution Medicines · Full Time · 2 months ago
Revolution Medicines
🌎 Switzerland ⭐ 10+ yrs exp 💼 Healthcare
The Senior Director will define and execute the medical strategy for oncology products across midsized European markets. This role involves leading scientific exchange, managing KOL relationships, and ensuring alignment between global strategy and local healthcare needs.

Executive Director, Quality, Europe

Revolution Medicines · Full Time · 2 months ago
Revolution Medicines
🌎 Netherlands ⭐ 10+ yrs exp 💼 Others
The Executive Director will lead and oversee all Quality functions across the European region, ensuring compliance with GxP standards and regulatory requirements. They will partner with cross-functional teams to maintain a robust, inspection-ready quality system and support the transition from clinical to commercial operations.

Associate Director, Qualified Person, Europe

Revolution Medicines · Full Time · 2 months ago
Revolution Medicines
🌎 Netherlands ⭐ 10+ yrs exp 💼 Others
The Qualified Person is responsible for the certification and release of clinical and commercial medicinal products in compliance with EU GMP and regulatory dossiers. They provide strategic leadership for the Pharmaceutical Quality System and act as the primary representative during health authority inspections.

Senior Director, Payor and Health Systems Liaison, East

Revolution Medicines · Full Time · 2 months ago
Revolution Medicines
🌎 United States 💵 $264K - $290K per year ⭐ 10+ yrs exp 💼 Healthcare
The Payor and Health Systems Liaison will develop and execute scientific payer and access strategies to support patient access for oncology products. They will lead high-impact clinical and scientific engagements with payers, GPOs, and IDNs while integrating medical affairs and market access objectives.

Senior Director, Payor and Health Systems Liaison, West

Revolution Medicines · Full Time · 2 months ago
Revolution Medicines
🌎 United States 💵 $264K - $290K per year ⭐ 10+ yrs exp 💼 Healthcare
The Payor and Health Systems Liaison will develop and execute scientific payer and access strategies to support patient access for oncology products. They will engage with key external stakeholders, including payers, GPOs, and IDNs, to communicate clinical value and population health insights.

Director, Global Forecasting

Revolution Medicines · Full Time · 2 months ago
Revolution Medicines
🌎 United States 💵 $201K - $251K per year ⭐ 10+ yrs exp 💼 Finance
The Director of Global Forecasting will develop and maintain long-term forecast models and scenario plans to support product and portfolio decision-making. They will collaborate with cross-functional teams and regional leads to ensure alignment on key forecast assumptions and strategic insights.

Vice President Sales and Field Team - NSCLC

Revolution Medicines · Full Time · 2 months ago
Revolution Medicines
🌎 United States 💵 $294K - $367K per year ⭐ 10+ yrs exp 💼 Sales
The Vice President of Oncology Sales will architect and lead a national sales organization, overseeing product launch strategies and field execution. This role involves driving revenue growth, managing key account partnerships, and fostering a high-performance culture across cross-functional teams.

Senior Director, Medical Affairs, Spain

Revolution Medicines · Full Time · 2 months ago
Revolution Medicines
🌎 Spain ⭐ 10+ yrs exp 💼 Healthcare
The Senior Director of Medical Affairs will define and execute the local medical strategy for oncology products in Spain while serving as the primary medical voice within the leadership team. They are responsible for building the local medical team, fostering relationships with key opinion leaders, and ensuring alignment between global strategy and local healthcare needs.

Senior Director, Medical Affairs, Italy

Revolution Medicines · Full Time · 2 months ago
Revolution Medicines
🌎 Italy ⭐ 10+ yrs exp 💼 Healthcare
The Senior Director will define and execute the local medical strategy for oncology products in Italy, serving as the primary medical voice within the leadership team. They are responsible for building the local medical team, fostering relationships with key opinion leaders, and ensuring scientific excellence across all medical affairs activities.

Senior Director, Commercial Lead, UK

Revolution Medicines · Full Time · 2 months ago
Revolution Medicines
🌎 United Kingdom ⭐ 10+ yrs exp 💼 Others
The Senior Director, Commercial Lead is responsible for defining and executing the local commercial strategy for oncology products in the UK. This role involves building the commercial organization, driving launch performance, and ensuring alignment across medical, access, and marketing functions.

Associate Director, Global Pricing Strategy & Analytics

Revolution Medicines · Full Time · 2 months ago
Revolution Medicines
🌎 United States 💵 $177K - $221K per year ⭐ 5-10 yrs exp 💼 Software Development
The Associate Director will lead the development and execution of global pricing strategies and frameworks across the company's oncology portfolio. They will provide advanced analytics and insights to support value optimization, market access decisions, and cross-functional collaboration with commercial and regional teams.

Director, Medical Science Liaison, California

Revolution Medicines · Full Time · 2 months ago
Revolution Medicines
🌎 United States 💵 $236K - $259K per year ⭐ 10+ yrs exp 💼 Healthcare
The Medical Science Liaison will engage in peer-to-peer scientific dialogue with healthcare professionals and serve as a key liaison between the company and clinical study sites. They will also collaborate cross-functionally to support medical strategies, advisory boards, and the communication of clinical data.

Director, CMC Regulatory, Europe

Revolution Medicines · Full Time · 2 months ago
Revolution Medicines
🌎 Switzerland ⭐ 10+ yrs exp 💼 Legal
The Director will develop and execute regional CMC regulatory strategies to support clinical development, marketing authorizations, and lifecycle management in Europe. They will serve as the primary lead for interactions with the EMA and national competent authorities while providing strategic guidance across cross-functional teams.

Senior Director, Regional Medical Science Liaison Team Lead - West

Revolution Medicines · Full Time · 2 months ago
Revolution Medicines
🌎 United States 💵 $268K - $295K per year ⭐ 10+ yrs exp 💼 Healthcare
The Senior Director will manage and coach a regional field medical team while overseeing the implementation of field medical strategies and key performance indicators. They will also drive thought leader engagement, foster scientific exchange, and collaborate across functions to support clinical trial and launch planning.

Senior Manager, Compliance - Field Commercialization

Revolution Medicines · Full Time · 2 months ago
Revolution Medicines
🌎 United States 💵 $164K - $205K per year ⭐ 10+ yrs exp 💼 Legal
The Senior Manager will provide hands-on compliance support to commercial and medical field teams while implementing and enhancing a comprehensive field-facing compliance program. Responsibilities include designing field training, managing compliance policies, and conducting auditing and monitoring activities to ensure adherence to regulatory standards.

Senior Manager, Sales Operations & Analytics

Revolution Medicines · Full Time · 2 months ago
Revolution Medicines
🌎 United States 💵 $150K - $189K per year ⭐ 5-10 yrs exp 💼 Software Development
The Senior Manager will lead sales operations and analytics by translating commercial strategy into scalable processes and actionable insights for US field teams. They will oversee core enablement systems, incentive compensation, and field programs to ensure operational excellence and alignment.

Director, Global Value, Access & Pricing – CRC

Revolution Medicines · Full Time · 2 months ago
Revolution Medicines
🌎 United States 💵 $201K - $251K per year ⭐ 10+ yrs exp 💼 Others
The Director leads the development and execution of global pricing and market access strategies for CRC assets to ensure patient access across key markets. They collaborate with cross-functional teams to integrate payer and HTA requirements into clinical development and commercialization plans.

Senior Director, Biostatistics, Europe

Revolution Medicines · Full Time · 2 months ago
Revolution Medicines
🌎 Switzerland ⭐ 10+ yrs exp 💼 Others
The Senior Director will provide statistical leadership for European access strategies and regulatory submissions, ensuring alignment between clinical development and regional market access needs. They will oversee the execution of statistical analyses for value dossiers and support interactions with European regulatory bodies like the EMA.

Senior Director, Responsible Pharmacist (Pharmacien Responsable), France

Revolution Medicines · Full Time · 2 months ago
Revolution Medicines
🌎 France ⭐ 10+ yrs exp 💼 Healthcare
The Senior Director acts as the Responsible Pharmacist for the French territory, ensuring full compliance with the French Public Health Code across all pharmaceutical operations. They oversee regulatory affairs, quality assurance, pharmacovigilance, and medical information while leading the local pharmaceutical affairs team.

Senior Director, Real World Data & Analytics

Revolution Medicines · Full Time · 2 months ago
Revolution Medicines
🌎 United States 💵 $244K - $305K per year ⭐ 10+ yrs exp 💼 Software Development
The Senior Director will establish and lead the Real-World Data & Analytics group to support portfolio, Medical Affairs, and HEOR goals. They are responsible for overseeing high-quality RWE study design, statistical analysis, and providing subject matter expertise to inform clinical programs and regulatory submissions.