Senior Scientist, Molecular Design

 Posted 3 months ago
     
 $160K - $240K per year
  
5-10 years experience
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AI Summary

The scientist will design small molecules using in-house computational tools, lead chemistry efforts for pipeline projects, and manage external synthetic chemistry teams to meet project goals. Responsibilities also include utilizing company chemical technologies for library design and collaborating on the development of generative models for compound design.


Position Summary: Terray is currently seeking a motivated, creative, and experienced scientist to join our molecular design (MoDe) group. As part of the Computational and Data Sciences (CDS) team, the candidate will help drive hit validation and advance programs through hit‑to‑lead by using our unique chemical datasets and integrated wet‑lab + computational technologies. A hallmark of this role is the close, day‑to‑day partnership with our medicinal chemistry, biology, and ML teams. MoDe scientists work hand‑in‑hand with wet‑lab colleagues throughout each design–make–test cycle, ensuring fast experimental feedback, shared problem‑solving, and seamless connection between computational design and laboratory execution. Crucial for this execution is collaboration with machine learning and data science teams in CDS.

The core responsibilities of this position are:

  • Design small molecules with in-house, high-throughput computational tools using both structural models and ligand-based data from our proprietary screening platform
  • Lead chemistry efforts for multiple internal pipeline and partnered projects with ownership and clear communication of design strategies
  • Manage external synthetic chemistry team(s) to effectively prioritize work to reach project goals
  • Utilize Terray chemical technologies to design focus libraries to drive small molecule programs toward lead optimization
  • Collaborate on development and evaluation of models and generative tools for compound design with the machine learning team
  • Communicate molecular design strategy and outcomes to teams across the company


Experience and Qualifications: Part of Terray’s success is nurtured by a hands-on work environment where everyone is accountable, vested in a vision of excellence, and actively taking part in the success of the business. Terray supports a positive work environment where employees can feel engaged, recognized and empowered to be creative. 

Required Qualifications: 

  • BS/MS/Ph.D in computational, organic, or medicinal chemistry with 4+ years of industry experience 
  • Experience with the application of ligand- and structure-based computational tools for molecular design 
  • Fluent in optimization of ADME and safety issues with the ability to communicate team strategies 
  • Experience with triage of large data sets from virtual screens, DEL screens, and/or HTS 
  • Excellent communication skills with experience conveying medicinal chemistry results cross-functionally 
  • Proven, or developing, program leadership experience 
  • Familiarity with the management of external chemistry teams


Compensation Details: $160,000 - $240,000 (annually) depending on experience; participation in the Company's option plan; 3% retirement safe harbor contribution; fully-paid medical, dental, vision, life and disability benefits.  

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