Position Overview

Tyra Biosciences, Inc. is seeking a highly motivated and experienced VP of Medical Affairs to make impactful contributions to multiple oncology programs targeting disease areas with high unmet medical need. The successful candidate will be highly organized, self-motivated, and thrive in a dynamic, cross functional start-up environment.

This position is responsible for leading the strategic development and execution of medical affairs activities. This role will be responsible for shaping medical strategy, engaging with key stakeholders, and driving the evidence generation and communication plan to support our portfolio across all key markets.The ideal candidate is a visionary leader with deep expertise in medical affairs and commercial alignment. They will work closely with cross-functional teams, including R&D, Regulatory, Clinical Development, IR, and Corporate Development to ensure scientific integrity and medical excellence across all initiatives.

Key Responsibilities

• Strategic Leadership & Execution

  o Develop and execute comprehensive medical affairs strategies aligned with corporate and commercial objectives.

  o Serve as the primary medical affairs leader overseeing scientific communications, medical education, KOL engagement, real-world evidence (RWE) generation, and medical insights.

  o Partner with R&D and Clinical Development teams to provide medical expertise on pipeline assets and shape evidence generation plans.

• Key Stakeholder Engagement

  o Build and maintain strong relationships with Key Opinion Leaders (KOLs), healthcare professionals (HCPs), and payers to drive scientific exchange and advocacy.

  o Represent the company at scientific congresses, advisory boards, and industry forums to enhance the company’s reputation as a leader in the therapeutic space.

  o Provide scientific and medical leadership for investigator-initiated studies (IIS), post-marketing studies, and collaborative research initiatives.

• Medical Strategy & Communications

  o Oversee the development and execution of medical education programs, advisory boards, and scientific symposia.

  o Lead publication planning and execution, ensuring high-quality scientific dissemination across key medical journals and conferences.

  o Guide the development of medical and commercial materials, ensuring scientific accuracy and compliance with regulatory requirements.

• Cross-functional Collaboration & Compliance

  o Act as a bridge between Medical Affairs, Commercial, Market Access, and R&D teams, ensuring alignment on product positioning and medical differentiation.

  o Partner with regulatory and legal teams to ensure all medical activities comply with FDA, EMA, and other global regulatory requirements.

  o Provide leadership on initiatives to support value demonstration and payer engagement.

• Contribute or lead process improvement initiatives.

• Other duties as assigned.

Qualifications & Experience

• MD, PharmD, or PhD with extensive experience in Medical Affairs and Oncology

• 8 - 10+ years of experience in the pharmaceutical, biotechnology, or life sciences industry, with a strong background in global or US Medical Affairs

• Experience in genitourinary cancer, depth in bladder cancer a significant plus

• Proven track record of leading medical strategies and teams in a complex, matrixed environment.

• Strong understanding of clinical development, regulatory landscapes, and payer expectations in the US and/or major international markets.

• Experience in launch planning, scientific engagement, and evidence generation in a highly competitive therapeutic area.

• Deep expertise in medical communications, scientific publications, and external stakeholder engagement.

• Excellent leadership skills with the ability to influence cross-functional teams and drive execution.

• Direct contributions to high-impact publications, and product launches.

• Experience with the design and conduct of clinical trials and clinical operations

• Excellent communication skills, including ability to create new materials to be used for both internal and external audiences

• Demonstrated customer focus and orientation

• Evident ability to lead, create, innovate, and flex within a changing environment

• Demonstrated ability to respond and move projects forward with a sense of urgency, understanding the need for immediate communication and resolution.

• Innovative thinking and problem-solving skills, with strong analytical and strategic ability.

• Excellent written and verbal communication skills.

• Passion for working in a small, start-up biotech work environment– including being self-motivated and proactive.

• Ability to accommodate up to 20-30% travel or as business dictates.

Base Salary Range: $405,700 - $442,600 USD

Individual compensation will be determined based on factors such as work location, skills, education, training, and experience.

What we offer US-based Employees

• Competitive base, bonus, new hire and ongoing equity packages

• The starting compensation range(s) for this role is for a full-time employee (FTE) basis

• Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment

• Employer-paid Medical, dental, and vision insurance

• Employer-paid life insurance, AD&D, short-term disability, long-term disability, and EAP coverage

• 401(k) Plan with a fully vested company match 1:1 up to 4% of contributions

• Employee Stock Purchase Plan

• 14 -18 paid holidays, including office closure between December 25th and January 1st

• Flexible vacation

• Sick time

• Fitness Program

• Get Outdoors Program

• Paid parental leave benefit

• Tuition assistance

Equal Opportunity Employer

Tyra Biosciences is an equal opportunity employer committed to building a diverse and inclusive workforce. Employment decisions are made without regard to race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information, gender identity or expression, veteran status, or any other characteristic protected by applicable federal, state, or local laws.

Notice to Recruiters and Third-Party Agencies

The Talent Acquisition team manages the recruitment and employment process for Tyra. To protect the interests of all parties involved, Tyra will only accept resumes from a recruiter once a fully-executed search agreement is in place. Agencies are hereby specifically directed not to contact Tyra employees directly in an attempt to present candidates. Tyra will consider any candidate for whom an Agency and/or Recruiter has submitted an unsolicited resume to have been referred, free of any charges or fees.