Position Overview

The Senior Medical Science Liaison (Sr. MSL) is a field-based scientific expert responsible for establishing and advancing Tyra Biosciences’ medical presence in oncology, with a focus on urologic malignancies. This role will serve as a primary scientific interface between Tyra and the oncology/urology community, supporting clinical development, data generation, and pre-commercial readiness for dabogratinib and future pipeline programs.

This position requires a high degree of scientific expertise, autonomy, and executional focus, with direct investigator engagement, Key Opinion Leader (KOL) engagement, clinical trial support, and insights generation in a growing biotech environment. The Sr. MSL will serve as a key scientific partner to internal teams and external healthcare professionals.

Key Responsibilities

• Lead and drive clinical trial and investigator support

• Proactively engage investigators and research staff in scientific discussions related to ongoing clinical trials, driving awareness and visibility of oncology programs

• Identify, develop, and maintain peer-to-peer scientific relationships with Key Opinion Leaders (KOLs) and healthcare professionals

• Collect, synthesize, and communicate actionable field insights to internal teams

• Identify emerging trends, competitive dynamics, and evolving standards of care in genitourinary oncology/urology

• Support scientific data dissemination and medical education initiatives

• Execute the scientific engagement plan

• Support Tyra’s presence at major oncology and urology congresses

• Maintain a high level of scientific expertise in oncology and urology

• Effectively collaborate with medical affairs, clinical development, clinical operations, and other cross-functional partners, ensuring alignment across programs

• Conduct all activities in accordance with regulations and company SOPs

• Facilitate problem-solving and conflict resolution with internal and external stakeholders to reduce issues / remove roadblocks and keep teams on track with key deliverables

• Proactively work with cross-functional teams to develop, progress, and accelerate program goals

• Serve as a role model within and outside of Medical Affairs in problem identification, cross functional collaboration, and implementation of planned resolutions

Qualifications & Experience

• Advanced scientific degree required: MD, PharmD, or PhD

• Minimum 5+ years of MSL experience in oncology or urology (preferred) in the biotechnology or pharmaceutical industry, independently managing a large geographic territory

• Strong track record of supporting clinical trials in a late-stage or pre-commercial setting

• Late-stage oncology drug development (Phase 3) experience required, experience in bladder cancer a plus

• Proven track record of effectively networking and building new relationships

• Excellent communication and presentation skills

· Demonstrated success in advancing drug candidates to development

• Ability to provide technical advice and assist with problem resolution

• Prior experience working in a small, start-up biotech work environment preferred

• Strong analytical and strategic ability

• Ability to work independently and to multi-task

• Ability to change pace and tasks as needed and to work in a fast-paced environment

• Proficient in MS Outlook/Word/Excel/PowerPoint

• Must be able to travel extensively (~60-70%), primarily in the U.S. but also internationally as needed

Base Salary Range: $238,467 - $250,800 USD

Individual compensation will be determined based on factors such as work location, skills, education, training, and experience.

What we offer US-based Employees

• Competitive base, bonus, new hire and ongoing equity packages

• The starting compensation range(s) for this role is for a full-time employee (FTE) basis

• Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment

• Employer-paid Medical, dental, and vision insurance

• Employer-paid life insurance, AD&D, short-term disability, long-term disability, and EAP coverage

• 401(k) Plan with a fully vested company match 1:1 up to 4% of contributions

• Employee Stock Purchase Plan

• 14 -18 paid holidays, including office closure between December 25th and January 1st

• Flexible vacation

• Sick time

• Fitness Program

• Get Outdoors Program

• Paid parental leave benefit

• Tuition assistance

Equal Opportunity Employer

Tyra Biosciences is an equal opportunity employer committed to building a diverse and inclusive workforce. Employment decisions are made without regard to race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information, gender identity or expression, veteran status, or any other characteristic protected by applicable federal, state, or local laws.

Notice to Recruiters and Third-Party Agencies

The Talent Acquisition team manages the recruitment and employment process for Tyra. To protect the interests of all parties involved, Tyra will only accept resumes from a recruiter once a fully-executed search agreement is in place. Agencies are hereby specifically directed not to contact Tyra employees directly in an attempt to present candidates. Tyra will consider any candidate for whom an Agency and/or Recruiter has submitted an unsolicited resume to have been referred, free of any charges or fees.