Simulations Plus stands as a global leader in model-informed and AI-accelerated drug development. We create value for our clients by accelerating the discovery, development, and commercialization of pharmaceuticals and other products through innovative science-based software and consulting solutions.

Leadership truly cares about maintaining a positive culture and employee well-being. We offer fully remote work, flexible schedules, and generous vacation policy along with affordable health coverage, annual bonus, and more! Check out how much our employees love working here: https://www.comparably.com/companies/simulations-plus.

The Senior Scientist I will lead or contribute to the technical execution of consulting projects using Quantitative Systems Pharmacology (QSP) and/or Toxicology (QST) models and methodologies. Frequently, consulting projects are conducted in Simulations Plus models, leveraging technical expertise in MATLAB or THALES.

Other work can include technical expertise in SimBiology, Julia, Monolix, as well as script generation using MATLAB, R, Python, etc. Consulting projects also leverage knowledge of multiple therapeutic areas including oncology, hepatology, metabolic diseases, pulmonary diseases, and inflammatory and immune diseases, as well as adverse events (e.g., liver injury, lung injury, cytopenias, cytokine release syndrome).

Department: Strategic Consulting Services/Quantitative Systems Pharmacology

Internal Grade: 13

Direct Reports: Optional

Status: Exempt

Location: Remote

Job Responsibilities:

Design, write, test, and use computer code to build and maintain the sub-model(s), representing core cellular, molecular, and/or biochemical processes in a given model
Represent compound pharmacodynamics (PD) and/or mechanism of action (MoA), including translating laboratory data into model parameters and curation of clinical data for calibration/validation
Learn and effectively utilize the company agentic AI solutions for technical work
Lead or contribute to the activities required for successful completion of all goals within consulting projects
Lead or contribute (as time allows) to R&D efforts, including updating the “license-ready” versions of the various models and supporting ongoing development of QST models of liver injury (i.e., the DILI-sim consortium)
Combine technical and project management work, including components such as systems pharmacology modeling, software code development, and maintenance in designated software environments
Develop plans to complete all tasks and provide all deliverables within a time frame consistent with the services agreement signed with the sponsor
Identify and suggest mitigation strategies for risks to successful project completion on time and on budget
Schedule the necessary meetings including internal and external collaborators
Exert leadership in the areas of report and presentation preparation, including evidence of minimal required supervision and providing thoughtful feedback on messaging
Lead consulting projects, upon demonstrating the necessary technical and project management skills and availability of a suitable project
Identify and initiate departmental activities that support growth or improved efficiency in the QSP team
Participate in preparation and review of joint manuscripts between the company and the sponsor
Manage the effort expended for a given project to remain consistent with the resources allocated for the project per the signed contract
Publish work in scientific journals, with minimal review required by their supervisor, including documentation preparation, text development, figure development, and correspondence with editors and peer reviewers
Oversee and supervise the technical work of others and mentor less experienced scientists
Train others on QSP/QST and the various models
Other duties as assigned

Qualifications:

5+ years of QSP/QST modeling experience or demonstration of the equivalent skill sets
Proficiency in mathematics, dynamic systems, drug development, pharmacology
General knowledge of relevant therapeutic areas, including clinical endpoints and underlying cell and molecular biology and/or biochemistry
Experience with MATLAB, THALES, Julia, SimBiology, Monolix, GastroPlus™, and/or C++ programming
Experience with PBPK, PK, popPK and/or PKPD modeling
Basic familiarity with large-language models and agentic AI
Understand how to apply modeling and simulation for maximum impact and effective means to communicate to non-modeling audiences
Strong verbal and written communication skills
Maintains a positive attitude while interacting with colleagues and clients
Must be able to multitask and have good organizational skills
Self-motivated with ability to work with minimal supervision
Occasional travel for conferences, meeting, and training

Education:

Master’s degree in pharmaceutical science, biomedical engineering, or related life sciences field
PhD in pharmaceutical science, biomedical engineering, or related life sciences field preferred

Simulations Plus

Senior Scientist I, QSP/QST Consulting Services

Create a cover letter for this job

Automatically Apply to the Best Remote Jobs

Similar Jobs

AI Trainer

Case Specialist

Lead - Specialists (Digital Solutions)

Sr Advisory Solution Consultant- US Public Sector- Moveworks

Elektroniker / Elektriker (m/w/d) - Region Köln

Major Gift Officer - Regional Director